Technology Process of 10b-(3-benzyloxy-1-hydroxy-propyl)-1,4,5,10b-tetrahydro-2H-7,9-dioxa-3a-aza-dicyclopenta[a,g]naphthalen-3-one
There total 8 articles about 10b-(3-benzyloxy-1-hydroxy-propyl)-1,4,5,10b-tetrahydro-2H-7,9-dioxa-3a-aza-dicyclopenta[a,g]naphthalen-3-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
boron trifluoride diethyl etherate;
In
dichloromethane;
at -45 - 0 ℃;
for 1h;
DOI:10.1021/ol017114f
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 95 percent / imidazole / dimethylformamide / 20 °C
2.1: n-BuLi / tetrahydrofuran / -5 °C
2.2: HMPA / tetrahydrofuran / 0 °C
3.1: 45percent HF / acetonitrile / 20 °C
4.1: 84 percent / NaClO2; NaClP; TEMPO / aq. phosphate buffer; acetonitrile / 35 °C / pH 6.86
5.1: 88 percent / DEPC; Et3N / tetrahydrofuran / 20 °C
6.1: 94 percent / LHMDS; AgOTf / toluene; hexane / 3 h / 65 - 70 °C
7.1: dimethyldioxirane / 0.58 h / -78 - -30 °C
8.1: BF3*OEt2 / CH2Cl2 / 1 h / -45 - 0 °C
With
1H-imidazole; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; n-butyllithium; boron trifluoride diethyl etherate; silver trifluoromethanesulfonate; 3,3-dimethyldioxirane; triethylamine; diethyl dicarbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; phosphate buffer; hexane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol017114f
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-BuLi / tetrahydrofuran / -5 °C
1.2: HMPA / tetrahydrofuran / 0 °C
2.1: 45percent HF / acetonitrile / 20 °C
3.1: 84 percent / NaClO2; NaClP; TEMPO / aq. phosphate buffer; acetonitrile / 35 °C / pH 6.86
4.1: 88 percent / DEPC; Et3N / tetrahydrofuran / 20 °C
5.1: 94 percent / LHMDS; AgOTf / toluene; hexane / 3 h / 65 - 70 °C
6.1: dimethyldioxirane / 0.58 h / -78 - -30 °C
7.1: BF3*OEt2 / CH2Cl2 / 1 h / -45 - 0 °C
With
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; n-butyllithium; boron trifluoride diethyl etherate; silver trifluoromethanesulfonate; 3,3-dimethyldioxirane; triethylamine; diethyl dicarbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; phosphate buffer; hexane; dichloromethane; toluene; acetonitrile;
DOI:10.1021/ol017114f
![1-(2-benzo[1,3]dioxol-5-yl-ethyl)-5-(3-benzyloxy-1-hydroxy-propyl)-5-methoxy-pyrrolidin-2-one](/Databaselist/images/loading.webp)
