1-phenyl-1-benzarsole

Base Information

• Chemical Name: 1-phenyl-1-benzarsole
• CAS No.: 152554-98-8
• Molecular Formula: C₁₄H₁₁As
• Molecular Weight: 254.163
• Mol file: 152554-98-8.mol

Synonyms:1-phenyl-1-benzarsole

Chemical Property of 1-phenyl-1-benzarsole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phenyl-1-benzarsole

There total 11 articles about 1-phenyl-1-benzarsole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-phenyl-2-trimethylsilylbenzo[b]arsole (152554-91-1) → 1-phenyl-1-benzarsole (152554-98-8)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1248/cpb.42.1437

Reference yield:

1-Phenyl-2-(trimethylsilyl)acetylene (2170-06-1) → 1-phenyl-1-benzarsole (152554-98-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) DIBAL-H, 2.) NBS / 1.) hexane, RT, 10 h, 2.) 0 deg C

2: 1.) BuLi / 1.) ether, hexane, RT, 2 h, 2.) ether, hexane, RT, 20 h

3: 97 percent / TBAF / tetrahydrofuran / 2 h / Heating

With N-Bromosuccinimide; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; In tetrahydrofuran;

DOI:10.1248/cpb.42.1437

Reference yield:

1-Bromo-2-iodobenzene (583-55-1) → 1-phenyl-1-benzarsole (152554-98-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 91 percent / Pd(PPh₃)2Cl₂, CuI, Et₂NH / 3.5 h / Ambient temperature

2: 1.) DIBAL-H, 2.) NBS / 1.) hexane, RT, 3 d, 2.) hexane, a) -20 deg C, 30 min, b) RT, 1 h

3: 1.) BuLi / 1.) ether, hexane, RT, 2 h, 2.) ether, hexane, RT, 20 h

4: 97 percent / TBAF / tetrahydrofuran / 2 h / Heating

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; n-butyllithium; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; diethylamine; In tetrahydrofuran;

DOI:10.1248/cpb.42.1437

upstream raw materials:

bromostyrene

dichlorophenylarsine

(Z)-β-bromostyrene

1-phenyl-2-trimethylsilylbenzo[b]arsole