N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

Base Information

Chemical Name:N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide
CAS No.:1384054-34-5
Molecular Formula:C₃₀H₂₇N₃O₂
Molecular Weight:461.563
Hs Code.:

Synonyms:N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

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Chemical Property of N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

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Technology Process of N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

There total 5 articles about N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 168626-54-8
N-[4-(5-oxo-2,3,4,5-tetrahydro-1H-benzazepine-1-carbonyl)phenyl]biphenyl-2-carboxamide

: 1384054-34-5
N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

Guidance literature:: With ammonium acetate; sodium cyanoborohydride; In methanol; at 100 ℃; under 750.075 Torr; Microwave irradiation;
DOI:10.1021/jm3006146

Reference yield:

: 180340-04-9
methyl 4-([1,1′-biphenyl]-2-ylcarboxamido)benzoate

: 1384054-34-5
N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; acetic acid / 4 h / Reflux

2.1: thionyl chloride / dichloromethane / 20 °C

2.2: 4 h / 0 °C

3.1: ammonium acetate; sodium cyanoborohydride / methanol / 100 °C / 750.08 Torr / Microwave irradiation

With hydrogenchloride; thionyl chloride; ammonium acetate; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane;
DOI:10.1021/jm3006146

Reference yield:

: 168626-74-2
4-[([1,1'-Biphenyl]-2-carbonyl)amino]benzoic Acid

: 1384054-34-5
N-(4-(5-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)phenyl)-[1,1′-biphenyl]-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / dichloromethane / 20 °C

1.2: 4 h / 0 °C

2.1: ammonium acetate; sodium cyanoborohydride / methanol / 100 °C / 750.08 Torr / Microwave irradiation

With thionyl chloride; ammonium acetate; sodium cyanoborohydride; In methanol; dichloromethane;
DOI:10.1021/jm3006146