{6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Base Information

Chemical Name:{6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester
CAS No.:1451093-64-3
Molecular Formula:C₂₆H₂₀Cl₂O₄S
Molecular Weight:499.414
Hs Code.:

Synonyms:{6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

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Chemical Property of {6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Chemical Property:

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Technology Process of {6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

There total 10 articles about {6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1451093-63-2
{6-chloro-4-[4-(4-chloro-phenylsulfanyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

: 1451093-64-3
{6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1451092-95-7
(6-chloro-3-methyl-4-trifluoromethanesulfonyloxy-naphthalen-2-yl)-acetic acid methyl ester

: 1451093-64-3
{6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,2-dimethoxyethane / 2 h / Reflux; Inert atmosphere

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1468-68-4
6-chloro-4-hydroxy-3-methyl-naphthalene-2-carboxylic acid

: 1451093-64-3
{6-chloro-4-[4-(4-chloro-benzenesulfonyl)-phenyl]-3-methyl-naphthalen-2-yl}-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 5 h / 0 - 60 °C

2: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Reflux; Inert atmosphere

3: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C

4: triethylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate / N,N-dimethyl-formamide / 16 h / 90 °C / Inert atmosphere

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / water; 1,2-dimethoxyethane / 2 h / Reflux; Inert atmosphere

7: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 20 °C

With tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium hydrogencarbonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;