2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

Base Information

Chemical Name:2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester
CAS No.:852700-61-9
Molecular Formula:C₃₇H₃₉NO₉
Molecular Weight:641.718
Hs Code.:

Synonyms:2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

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Chemical Property of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

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Technology Process of 2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

There total 4 articles about 2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.8%

: 852700-60-8
6-bromo-hex-4-enoic acid 2-oxo-2-phenyl-ethyl ester

: 129460-09-9,134098-70-7
Fmoc-Asp-O-t-Bu

: 852700-61-9
2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 15h;
DOI:10.1021/ol0502578

Reference yield: 75.0%

: 1239683-64-7
hex-5-enoic acid 2-oxo-2-phenylethyl ester

: 129460-09-9,134098-70-7
Fmoc-Asp-O-t-Bu

: 852700-61-9
2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

: 2-(9H-fluoren-9-ylmethoxycarbonylamino)succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)pent-2-enyl]ester

Guidance literature:: With tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; 2-phenyl-1,4-benzoquinone; In dichloromethane; at 41 ℃; for 72h; optical yield given as %de; Molecular sieve;
DOI:10.1021/ja104826g

Reference yield:

: 300710-48-9
6-bromo-hex-4-enoic acid tert-butyl ester

: 852700-61-9
2-(9H-fluoren-9-ylmethoxycarbonylamino)-succinic acid 1-tert-butyl ester 4-[5-(2-oxo-2-phenylethoxycarbonyl)-pent-2-enyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 1 h / 20 °C

2: 6.02 g / KF / dimethylformamide / 0.83 h / 20 °C

3: 78.8 percent / K₂CO₃ / dimethylformamide / 15 h / 20 °C

With potassium fluoride; potassium carbonate; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/ol0502578