Technology Process of C19H16F3NOSe2
There total 5 articles about C19H16F3NOSe2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-iodo-2-methyl-phenol;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 0 ℃;
for 0.166667h;
With
tert.-butyl lithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.166667h;
selenium; C12H9ClF3NSe;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogenchloride; pyridine / ethanol / 2 h / Inert atmosphere; Reflux
2.1: tetrahydrofuran / 12.83 h / 20 - 80 °C / Reflux
2.2: 0.33 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; hexane / 1.5 h / -78 - -10 °C / Inert atmosphere
4.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1 h / 20 °C
5.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C
5.2: 0.17 h / -78 °C
With
pyridine; hydrogenchloride; N-chloro-succinimide; isopropylmagnesium chloride; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; ethanol; hexane; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrahydrofuran / 12.83 h / 20 - 80 °C / Reflux
1.2: 0.33 h / 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; hexane / 1.5 h / -78 - -10 °C / Inert atmosphere
3.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 1 h / 20 °C
4.1: isopropylmagnesium chloride / tetrahydrofuran / 0.17 h / 0 °C
4.2: 0.17 h / -78 °C
With
N-chloro-succinimide; isopropylmagnesium chloride; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; hexane; dichloromethane;
