methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

Base Information

Chemical Name:methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate
CAS No.:1364267-95-7
Molecular Formula:C₂₁H₂₃N₃O₃S
Molecular Weight:397.498
Hs Code.:

Synonyms:methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

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Chemical Property of methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

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Technology Process of methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

There total 7 articles about methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364268-16-5
1-(5-bromothiophen-3-yl)-N,N-dimethylmethanamine

: 1364267-61-7
C₁₄H₁₅BN₂O₅

: 1364267-95-7
methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; N,N-dimethyl-formamide; at 110 ℃; for 1h; Microwave irradiation;
DOI:10.1021/jm201683b

Reference yield:

: 1666-28-0
4-bromosalicylic acid

: 1364267-95-7
methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: sulfuric acid / 24 h / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / water; N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

6: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sulfuric acid; potassium acetate; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; bis(pinacol)diborane; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm201683b

Reference yield:

: 1364267-50-4
methyl 4-(2-amino-5-bromopyridin-3-yl)-2-methoxybenzoate

: 1364267-95-7
methyl 4-(2-amino-5-(4-((dimethylamino)methyl)thiophen-2-yl)pyridin-3-yl)-2-methoxybenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / N,N-dimethyl-formamide / 1.5 h / 100 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; N,N-dimethyl-formamide / 1 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; sodium carbonate; bis(pinacol)diborane; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm201683b