methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

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Chemical Name:methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate
CAS No.:1359852-91-7
Molecular Formula:C₂₃H₃₄N₂O₆
Molecular Weight:434.533
Hs Code.:

Synonyms:methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

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Chemical Property of methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

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Technology Process of methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

There total 7 articles about methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1359852-70-2
methyl 8-((2S)-1-(1-(4-(benzyloxy)-phenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

: 1359852-91-7
methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

Reference yield:

: 3946-32-5
suberic acid monomethyl ester

: 1359852-91-7
methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; 4-methyl-morpholine / dichloromethane / 20 °C / Inert atmosphere

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 0 - 20 °C / Inert atmosphere

3.2: 0 - 20 °C

4.1: potassium carbonate / acetone / 20 °C / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 4 h / 20 °C

With 4-methyl-morpholine; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1359852-73-5
methyl 8-((2S)-1-(1-hydroxy-3-(4-hydroxyphenyl)propan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

: 1359852-91-7
methyl 8-((2S)-1-(1-(4-hydroxyphenyl)-3-oxopropan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-8-oxooctanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h / 20 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / ethanol; tetrahydrofuran / 4 h / 20 °C

With hydrogen; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dimethyl sulfoxide; acetone;