[1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine

Base Information

• Chemical Name: [1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine
• CAS No.: 146874-44-4
• Molecular Formula: C₁₇H₁₈N₄O₃
• Molecular Weight: 326.355
• Mol file: 146874-44-4.mol

Synonyms:[1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine

Chemical Property of [1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine

There total 1 articles about [1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

morpholine (110-91-8,99108-56-2) + 3-nitro-4-azidopyridine (85868-30-0) + phenylacetaldehyde (122-78-1) → [1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine (146874-44-4)

Guidance literature:

In benzene; for 12h; Ambient temperature;

DOI:10.1055/s-1992-26335

Reference yield: 55.0%

[1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine (146874-44-4) → 2-Morpholin-4-yl-3-phenyl-pyrido[3,4-b]pyrazine 4-oxide (146874-50-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 5h; Heating;

DOI:10.1055/s-1992-26335

Reference yield:

[1-Morpholin-4-yl-2-phenyl-eth-(Z)-ylidene]-(3-nitro-pyridin-4-yl)-amine (146874-44-4) → 2-morpholino-3-phenylpyrido<3,4-b>pyrazine

Guidance literature:

Multi-step reaction with 2 steps

1: 55 percent / EtONa / ethanol / 5 h / Heating

2: 97 percent / Na₂S₂O₄ / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature; also with quinoxaline 1-oxides, different reaction times

With sodium dithionite; sodium ethanolate; In tetrahydrofuran; ethanol; water;

DOI:10.1055/s-1992-26335

upstream raw materials:

morpholine

3-nitro-4-azidopyridine

phenylacetaldehyde

Downstream raw materials:

2-Morpholin-4-yl-3-phenyl-pyrido[3,4-b]pyrazine 4-oxide