5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine

Base Information

• Chemical Name: 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine
• CAS No.: 1155877-95-4
• Molecular Formula: C₁₉H₁₄ClF₂NO
• Molecular Weight: 345.776

Synonyms:5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine

Chemical Property of 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine

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Technology Process of 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine

There total 1 articles about 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-bromomethyl-3'-chloro-2-fluoro-6-methoxy-biphenyl (1155877-85-2) + (6-fluoropyridin-3-yl)boronic acid (351019-18-6) → 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine (1155877-95-4)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃;

Reference yield: 77.0%

5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine (1155877-95-4) + Azetidine-2-carboxylic acid (2517-04-6,20063-89-2) → 1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-azetidine-2-carboxylic acid (1155877-05-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 160 ℃; for 0.333333h;

Reference yield: 73.0%

5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-2-fluoro-pyridine (1155877-95-4) + D-Prolin (344-25-2,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (R)-1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-pyrrolidine-2-carboxylic acid (1155877-21-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 160 ℃; for 0.333333h;

upstream raw materials:

3-bromomethyl-3'-chloro-2-fluoro-6-methoxy-biphenyl

(6-fluoropyridin-3-yl)boronic acid

Downstream raw materials:

1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-azetidine-2-carboxylic acid

(S)-1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-azetidine-2-carboxylic acid

(R)-1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-azetidine-2-carboxylic acid

(S)-1-[5-(3'-chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-pyridin-2-yl]-pyrrolidine-2-carboxylic acid

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