5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Base Information

Chemical Name:5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide
CAS No.:1351066-95-9
Molecular Formula:C₂₉H₃₇N₃OSi
Molecular Weight:471.718
Hs Code.:

Synonyms:5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

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Chemical Property of 5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

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Technology Process of 5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

There total 4 articles about 5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1090409-09-8
3-(dimethylamino)-N-(quinolin-8-yl)benzamide

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 1351066-95-9
5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Guidance literature:: With cesium acetate; palladium diacetate; In toluene; at 110 ℃; for 15h; regioselective reaction; Inert atmosphere;
DOI:10.1021/ol203100u

Reference yield:

: 54263-82-0
3-(dimethylamino)benzoyl chloride

: 1351066-95-9
5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: cesium acetate; palladium diacetate / toluene / 15 h / 110 °C / Inert atmosphere

With cesium acetate; palladium diacetate; triethylamine; In dichloromethane; toluene;
DOI:10.1021/ol203100u

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1351066-95-9
5-(dimethylamino)-N-(8-quinolinyl)-2-((triisopropylsilyl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate

2: cesium acetate; palladium diacetate / toluene / 15 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; cesium acetate; palladium diacetate; silver nitrate; In toluene;
DOI:10.1021/ol203100u