2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

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Chemical Name:2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole
CAS No.:1613695-13-8
Molecular Formula:C₂₈H₃₃ClN₄O₃
Molecular Weight:509.048
Hs Code.:

Synonyms:2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

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Chemical Property of 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

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Technology Process of 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

There total 6 articles about 2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1857-56-3
3-(3-chloro-4-methoxyphenyl)propionic acid

: C₁₈H₂₆N₄O₂

: 1613695-13-8
2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; at 80 ℃; for 16h;
DOI:10.1021/ja412434f

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1613695-13-8
2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C

2.2: 4 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C

4.1: sodium dithionite / ethanol / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 16 h / 80 °C

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1021/ja412434f

Reference yield:

: 832114-00-8
3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole

: 1613695-13-8
2-[2-(3-chloro-4-methoxyphenyl)ethyl]-5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-[(2R)-2-(morpholin-4-yl)propyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate / 1,2-dimethoxyethane / 3 h / 80 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h / 20 °C

2.2: 4 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 70 °C

4.1: sodium dithionite / ethanol / 1 h / 80 °C

5.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate / 16 h / 80 °C

With sodium dithionite; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium hydrogencarbonate; potassium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; ethyl acetate; N,N-dimethyl-formamide; 1.1: |Suzuki Coupling;
DOI:10.1021/ja412434f