[(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: [(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 164472-81-5
• Molecular Formula: C₄₁H₅₇N₅O₈S
• Molecular Weight: 779.998
• Mol file: 164472-81-5.mol

Synonyms:[(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of [(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about [(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1,1-diethoxy-4-methylpentan-2-amine (164472-97-3) + Fmoc-Arg(Mtr)-OH (98930-01-9) → [(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (164472-81-5)

Guidance literature:

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1021/jm00013a002

Reference yield:

[(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (164472-81-5) → (S)-2-Amino-5-({amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-pentanoic acid ((S)-1-diethoxymethyl-3-methyl-butyl)-amide (164472-84-8)

Guidance literature:

With diethylamine; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1021/jm00013a002

Reference yield:

[(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butyl]-carbamic acid 9H-fluoren-9-ylmethyl ester (164472-81-5) → 8-[(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-formyl-3-methyl-butylcarbamoyl)-butylcarbamoyl]-octanoic acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: (Et)2NH / dimethylformamide / 25 °C

2: (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 25 °C

3: 1N aq. HCl / tetrahydrofuran / 25 °C

With 4-methyl-morpholine; hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; diethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm00013a002

upstream raw materials:

(S)-1,1-diethoxy-4-methylpentan-2-amine

Fmoc-Arg(Mtr)-OH

Downstream raw materials:

(S)-2-Amino-5-({amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-pentanoic acid ((S)-1-diethoxymethyl-3-methyl-butyl)-amide

8-[(S)-4-({Amino-[(E)-4-methoxy-2,3,6-trimethyl-benzenesulfonylimino]-methyl}-amino)-1-((S)-1-diethoxymethyl-3-methyl-butylcarbamoyl)-butylcarbamoyl]-octanoic acid methyl ester