2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

Base Information

Chemical Name:2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol
CAS No.:909796-72-1
Molecular Formula:C₂₉H₂₆ClNO₂
Molecular Weight:455.984
Hs Code.:

Synonyms:2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

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Chemical Property of 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

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Technology Process of 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

There total 5 articles about 2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1208128-87-3
2-(2-ortho(2-bromoethyl)phenylpropyl)tetrahydropyran ether

: 1208128-84-0
3-(2-(7-chloro-2-quinolyl)vinyl)benzonitrile

: 909796-72-1,1258428-71-5
2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

Guidance literature:: 2-(2-ortho(2-bromoethyl)phenylpropyl)tetrahydropyran ether; With magnesium; In tetrahydrofuran; Inert atmosphere;

3-(2-(7-chloro-2-quinolyl)vinyl)benzonitrile; In tetrahydrofuran; at 0 ℃; Reflux;

With hydrogenchloride; In tetrahydrofuran; water; for 6h; Reflux;

Reference yield:

: 577-16-2,122382-54-1
2-Methylacetophenone

: 909796-72-1,1258428-71-5
2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / -5 - 20 °C / Inert atmosphere

2.1: triphenylphosphine hydrobromide / dichloromethane / 48 h / 0 °C / Reflux

3.1: trimethylbenzylammonium hydroxide / dimethyl sulfoxide; methanol / 60 - 65 °C

4.1: phosphorus tribromide / diethyl ether / 0 - 20 °C

5.1: magnesium / tetrahydrofuran / Inert atmosphere

5.2: 0 °C / Reflux

5.3: 6 h / Reflux

With trimethylbenzylammonium hydroxide; triphenylphosphine hydrobromide; phosphorus tribromide; magnesium; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1208128-85-1
2-(2-orthomethylphenylpropyl)tetrahydropyrane ether

: 909796-72-1,1258428-71-5
2-(2-(3-(2-(7-chloro-2-quinolyl)vinyl)phenyl-3-oxopropyl)phenyl)propanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trimethylbenzylammonium hydroxide / dimethyl sulfoxide; methanol / 60 - 65 °C

2.1: phosphorus tribromide / diethyl ether / 0 - 20 °C

3.1: magnesium / tetrahydrofuran / Inert atmosphere

3.2: 0 °C / Reflux

3.3: 6 h / Reflux

With trimethylbenzylammonium hydroxide; phosphorus tribromide; magnesium; In tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide;