C₆₀H₇₉N₃O₁₀Si

Base Information

• Chemical Name: C₆₀H₇₉N₃O₁₀Si
• CAS No.: 173091-89-9
• Molecular Formula: C₆₀H₇₉N₃O₁₀Si
• Molecular Weight: 1030.39
• Mol file: 173091-89-9.mol

Synonyms:C₆₀H₇₉N₃O₁₀Si

Chemical Property of C₆₀H₇₉N₃O₁₀Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₀H₇₉N₃O₁₀Si

There total 18 articles about C₆₀H₇₉N₃O₁₀Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one (136159-65-4,96930-27-7) → C60H79N3O10Si (173091-89-9)

Guidance literature:

Multi-step reaction with 10 steps

1: 1.) NaHMDS / 1.) THF, -78 deg C, 15 min, 2.) THF, from -78 deg C to 0 deg C, 60 min

2: 1.) n-BuLi / 1.) hexane, THF, 0 deg C, 2.) hexane, THF, 0 deg C, 15 min

3: LAH / tetrahydrofuran / 0.5 h / 0 °C

4: 97 percent / imidazole / dimethylformamide / Ambient temperature

5: 1.) O₃, 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, RT, overnight

6: CHCl₃; toluene / 4 h

7: KHMDS / 1.) THF, toluene, 20 min, 2.) THF, toluene, 0 deg C, 25 min

8: 1.) NMO, OsO₄, 2.) 2percent aq. NaOH, 3.) Pb(OAc)4

9: CHCl₃; toluene / 4 h

10: 1.) KHMDS / 1.) THF, toluene, RT, 15 min, 2.) THF, toluene, 0 deg C, 15 min

With 1H-imidazole; lead(IV) acetate; sodium hydroxide; osmium(VIII) oxide; lithium aluminium tetrahydride; n-butyllithium; N-methyl-2-indolinone; sodium hexamethyldisilazane; potassium hexamethylsilazane; ozone; triphenylphosphine; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/ja00150a011

Reference yield:

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane (98760-08-8) → C60H79N3O10Si (173091-89-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) KHMDS, 2.) Et₂AlCl / 1.) THF, toluene, -78 deg C, 10 min, 2.) THF, toluene, heptane, -74 deg C, 10 min

2: 91 percent / p-TsOH*H₂O / acetone / 72 h / Ambient temperature

3: 1 N methanolic NaOH / methanol / 72 h / Heating

4: K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

5: 96 percent / Pd(Ph₃P)4, dimedone / tetrahydrofuran / Ambient temperature

6: CHCl₃; toluene / 4 h

7: 1.) KHMDS / 1.) THF, toluene, RT, 15 min, 2.) THF, toluene, 0 deg C, 15 min

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylaluminium chloride; potassium hexamethylsilazane; potassium carbonate; dimedone; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1021/ja00150a011

Reference yield:

(2R,4R)-4-Benzyl-2-tert-butyl-5-oxo-oxazolidine-3-carboxylic acid allyl ester (147240-29-7) → C60H79N3O10Si (173091-89-9)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.) KHMDS, 2.) Et₂AlCl / 1.) THF, toluene, -78 deg C, 10 min, 2.) THF, toluene, heptane, -74 deg C, 10 min

2: 91 percent / p-TsOH*H₂O / acetone / 72 h / Ambient temperature

3: 1 N methanolic NaOH / methanol / 72 h / Heating

4: K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

5: 96 percent / Pd(Ph₃P)4, dimedone / tetrahydrofuran / Ambient temperature

6: CHCl₃; toluene / 4 h

7: 1.) KHMDS / 1.) THF, toluene, RT, 15 min, 2.) THF, toluene, 0 deg C, 15 min

With sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; diethylaluminium chloride; potassium hexamethylsilazane; potassium carbonate; dimedone; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1021/ja00150a011

upstream raw materials:

Allyl chloroformate

(S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

(2R,4R)-4-Benzyl-2-tert-butyl-5-oxo-oxazolidine-3-carboxylic acid allyl ester

Downstream raw materials:

(4S,5S)-4-Benzyl-5-[(2S,5'S)-5'-benzyl-4-((R)-1-tert-butylcarbamoyl-2-phenyl-ethyl)-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-5'-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

{(1S,2S)-1-Benzyl-3-[(2S,5'S)-5'-benzyl-4-((R)-1-tert-butylcarbamoyl-2-phenyl-ethyl)-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-5'-yl]-2-hydroxy-propyl}-carbamic acid (S)-(tetrahydro-furan-3-yl) ester

(4S,5S)-4-Benzyl-5-[(2S,5'S)-5'-benzyl-4-((R)-1-carbamoyl-2-phenyl-ethyl)-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-5'-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

(4S,5S)-4-Benzyl-5-[(2S,5'S)-5'-benzyl-4-((R)-1-carboxy-2-phenyl-ethyl)-2-isobutyl-3,4'-dioxo-2,3,4',5'-tetrahydro-1H,1'H-[2,3']bipyrrolyl-5'-ylmethyl]-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

Refernces