Technology Process of N-benzyloxycarbonyl-4,4-difluoro-D-glutamic acid 5-tert-butyl ester
There total 6 articles about N-benzyloxycarbonyl-4,4-difluoro-D-glutamic acid 5-tert-butyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trimethyltin(IV) hydroxide;
In
1,2-dichloro-ethane;
at 70 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jo2018679
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydrogencarbonate / water / 0 - 23 °C
2: methanol; hexane; toluene / 20 °C
3: lithium hydroxide / methanol; water / 0.03 h / 0 °C
4: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / N,N-dimethyl acetamide / 18 h / 55 °C
5: subtilisin Carlsberg from Bacillus licheniformis / dimethyl sulfoxide / 13 h / 23 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
6: trimethyltin(IV) hydroxide / 1,2-dichloro-ethane / 3 h / 70 °C / Inert atmosphere
With
N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; potassium carbonate; trimethyltin(IV) hydroxide; lithium hydroxide; subtilisin Carlsberg from Bacillus licheniformis;
In
methanol; hexane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo2018679
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydrogencarbonate / water / 0 - 23 °C
2: methanol; hexane; toluene / 20 °C
3: lithium hydroxide / methanol; water / 0.03 h / 0 °C
4: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / N,N-dimethyl acetamide / 18 h / 55 °C
5: subtilisin Carlsberg from Bacillus licheniformis / dimethyl sulfoxide / 13 h / 23 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction
6: trimethyltin(IV) hydroxide / 1,2-dichloro-ethane / 3 h / 70 °C / Inert atmosphere
With
N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; potassium carbonate; trimethyltin(IV) hydroxide; lithium hydroxide; subtilisin Carlsberg from Bacillus licheniformis;
In
methanol; hexane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jo2018679
