4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

Base Information

Chemical Name:4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine
CAS No.:1073136-58-9
Molecular Formula:C₃₂H₃₀FN₃O₂
Molecular Weight:507.608
Hs Code.:

Synonyms:4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

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Chemical Property of 4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

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Technology Process of 4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

There total 6 articles about 4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1073136-56-7
4-{[(3R)-1-benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-iodofuro[2,3-d]pyrimidine

: 1993-03-9
o-fluorophenylboronic acid

: 1073136-58-9
4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; dimethyl sulfoxide; at 80 ℃; for 15h;

Reference yield:

: 4748-78-1
4-ethylbenzylaldehyde

: 1073136-58-9
4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-dimethylammonium chloride; potassium fluoride / xylene / 22 h / 160 - 175 °C

2.1: ethanol / 0.5 h / 60 - 70 °C

2.2: 21 h / 60 °C / Reflux

3.1: N-iodo-succinimide / tetrachloromethane; acetonitrile / 2 h / Reflux

4.1: trichlorophosphate / 1 h / Reflux

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h

5.2: 5 h / 20 °C

6.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 15 h / 80 °C

With potassium fluoride; N-iodo-succinimide; N,N-dimethylammonium chloride; sodium hydride; sodium carbonate; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; tetrachloromethane; ethanol; water; dimethyl sulfoxide; acetonitrile; xylene; mineral oil;

Reference yield:

: 1073136-54-5
4-chloro-5-(4-ethylphenyl)-6-iodofuro[2,3-d]pyrimidine

: 1073136-58-9
4-{[(3R)-1-Benzylpiperidin-3-yl]oxy}-5-(4-ethylphenyl)-6-(2-fluorophenyl)furo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h

1.2: 5 h / 20 °C

2.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; dimethyl sulfoxide / 15 h / 80 °C

With sodium hydride; sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; water; dimethyl sulfoxide; mineral oil;