2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid

Base Information

Chemical Name:2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid
CAS No.:34626-05-6
Molecular Formula:C₁₀H₇ClN₂O₂
Molecular Weight:222.631
Hs Code.:
European Community (EC) Number:885-940-7

Synonyms:34626-05-6;2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid;2-(4-CHLOROPHENYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID;SCHEMBL14952963;MFCD09831995;AKOS011535284;AKOS022688328;BB 0296195;FT-0733406;EN300-1264725

Suppliers and Price of 2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:222.0196052
Heavy Atom Count:15
Complexity:242

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC=C(N2)C(=O)O)Cl

Technology Process of 2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid

There total 5 articles about 2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 33469-15-7
2-(4-chlorophenyl)-5-(trifluoromethyl)-1H-imidazole

: 34626-05-6
2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid

Guidance literature:: With water; sodium hydroxide; In ethanol; for 24h; Reflux;
DOI:10.1021/acs.jmedchem.7b00179

Reference yield: 57.0%

: 33469-15-7
2-(4-chlorophenyl)-4-trifluoromethyl-1H-imidazole

: 34626-05-6
2-(4-chlorophenyl)-4-carboxy-1H-imidazole

Guidance literature:: With sodium hydroxide; at 90 ℃; for 1h;
DOI:10.1021/jm991154w

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 34626-05-6
2-(4-chlorophenyl)-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium acetate / water / 0.5 h / 90 °C

1.2: 20 °C

2.1: sodium hydroxide; water / ethanol / 24 h / Reflux

With water; sodium acetate; sodium hydroxide; In ethanol; water;
DOI:10.1021/acs.jmedchem.7b00179