trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid

Base Information

• Chemical Name: trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid
• CAS No.: 951656-14-7
• Molecular Formula: C₁₈H₁₂O₄
• Molecular Weight: 292.291
• Mol file: 951656-14-7.mol

Synonyms:trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid

Chemical Property of trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid

There total 4 articles about trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid tert-butyl ester (951656-12-5) → trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid (951656-14-7)

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 1h;

DOI:10.1021/jm0703136

Reference yield:

3-(2-bromoacetyl)benzaldehyde (951656-08-9) → trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid (951656-14-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / K₂CO₃ / acetonitrile / Heating

2: 40 percent / aq. NaOH; NEt₃ / CH₂Cl₂ / 1 h / 20 °C

3: 95 percent / TFA / 1 h / 20 °C

With sodium hydroxide; potassium carbonate; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile; 2: Wittig olefination;

DOI:10.1021/jm0703136

Reference yield:

3-(benzofuran-2-carbonyl)benzaldehyde (951656-10-3) → trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid (951656-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / aq. NaOH; NEt₃ / CH₂Cl₂ / 1 h / 20 °C

2: 95 percent / TFA / 1 h / 20 °C

With sodium hydroxide; triethylamine; trifluoroacetic acid; In dichloromethane; 1: Wittig olefination;

DOI:10.1021/jm0703136

upstream raw materials:

trans-3-[3-(benzofuran-2-carbonyl)phenyl]acrylic acid tert-butyl ester

3-(2-bromoacetyl)benzaldehyde

3-(benzofuran-2-carbonyl)benzaldehyde

3-acetylbenzaldehyde

Downstream raw materials:

trans-3-[3-(benzofuran-2-carbonyl)phenyl]-N-(tetrahydropyran-2-yloxy)acrylamide

Refernces