(R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Base Information

Chemical Name:(R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine
CAS No.:1285464-74-5
Molecular Formula:C₁₆H₁₃F₄N₅
Molecular Weight:351.306
Hs Code.:

Synonyms:(R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

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Chemical Property of (R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

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Technology Process of (R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

There total 6 articles about (R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: trifluoromethanesulfonic acid 2,2,2-trifluoro-1(S)-(4-fluorophenyl)ethyl ester

: 68210-20-8
7,8-dihydro-5-methyl-6H-pyrrolo<3,2-e><1,2,4>triazolo<1,5-a>pyrimidine

: 1285464-74-5
(R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: 7,8-dihydro-5-methyl-6H-pyrrolo<3,2-e><1,2,4>triazolo<1,5-a>pyrimidine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; for 0.5h;

trifluoromethanesulfonic acid 2,2,2-trifluoro-1(S)-(4-fluorophenyl)ethyl ester; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 517-23-7,594837-91-9,98634-97-0,313643-49-1
3-acetyl-2-oxo-4,5-dihydrofuran

: 1285464-74-5
(R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: boron trifluoride diethyl etherate / isopropyl methanesulfonate / 72.25 h / 20 °C

2.1: trichlorophosphate / ethanol / 5 h / 120 °C

3.1: sodium carbonate; ethanimidamide hydrochloride / ethanol / 8 h / 90 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

4.2: 20 °C

With ethanimidamide hydrochloride; boron trifluoride diethyl etherate; sodium hydride; sodium carbonate; trichlorophosphate; In ethanol; isopropyl methanesulfonate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 890085-08-2
(S)-4-fluoro-α,α,α-(trifluoromethyl)-benzenemethanol

: 1285464-74-5
(R)-5-methyl-8-[2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-7,8-dihydro-6H-pyrrolo[3,2-e][1,2,4]triazolo[1,5-a]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine / dichloromethane / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h

2.2: 20 °C

With 2,6-dimethylpyridine; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; mineral oil;