1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone

Base Information

• Chemical Name: 1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone
• CAS No.: 1364952-63-5
• Molecular Formula: C₂₅H₁₉BrF₂N₂O₂
• Molecular Weight: 497.339

Synonyms:1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone

Chemical Property of 1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone

Chemical Property:

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Technology Process of 1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone

There total 1 articles about 1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-bromo-2,2-difluoro-N-(4-methoxyphenyl)acetimidoyl chloride + 3-acetyl-2-phenylindole (17375-64-3) → 1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone (1364952-63-5)

Guidance literature:

3-acetyl-2-phenylindole; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1.33333h; Inert atmosphere;

2-bromo-2,2-difluoro-N-(4-methoxyphenyl)acetimidoyl chloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c2cc30207a

Reference yield: 90.0%

1-(1-(2-bromo-2,2-difluoro-1-((4-methoxyphenyl)imino)ethyl)-2-phenyl-1H-indol-3-yl)ethanone (1364952-63-5) → 1-(5,5-difluoro-6-((4-methoxyphenyl)imino)-5,6-dihydroindolo[2,1-a]isoquinolin-12-yl)ethanone (1364953-35-4)

Guidance literature:

With Wilkinson's catalyst; silver carbonate; In 1,4-dioxane; at 120 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c2cc30207a

upstream raw materials:

3-acetyl-2-phenylindole

Downstream raw materials:

1-(5,5-difluoro-6-((4-methoxyphenyl)imino)-5,6-dihydroindolo[2,1-a]isoquinolin-12-yl)ethanone

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