N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

Base Information

Chemical Name:N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine
CAS No.:1334294-33-5
Molecular Formula:C₁₈H₂₃ClN₄OSSi
Molecular Weight:407.011
Hs Code.:

Synonyms:N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

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Chemical Property of N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

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Technology Process of N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

There total 1 articles about N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1334294-33-5
N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonia / water / 8 h / 165 °C / 14251.4 Torr / Sealed tube; Microwave irradiation

1.2: pH 3

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 20 °C / Inert atmosphere; Cooling with ice

With 1H-imidazole; lithium aluminium tetrahydride; ammonia; sodium hydride; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1334294-33-5
N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: trans-4-{[4-(hydroxymethyl)-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyridinyl]amino}cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2: 190 °C

With tetrabutyl ammonium fluoride; In tetrahydrofuran;

Reference yield:

: 1334294-33-5
N-[6-chloro-4-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl][1,3]thiazolo[5,4-b]pyridin-2-amine

: trans-4-{[4-[(tetrahydro-2H-pyran-4-ylamino)methyl]-6-([1,3]thiazolo[5,4-b]pyridin-2-ylamino)-2-pyridinyl]amino}cyclohexanol (2Z)-2-butenedioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

2.1: 190 °C

3.1: manganese(IV) oxide / tetrahydrofuran / 70 °C

4.1: NaBH(OAc)3 / dichloromethane / 3 h / 20 °C

4.2: 0.5 h

5.1: methanol

With manganese(IV) oxide; NaBH(OAc)3; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol; dichloromethane;