(S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

Base Information

Chemical Name:(S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid
CAS No.:117653-26-6
Molecular Formula:C₂₂H₂₀I₂N₂O₅
Molecular Weight:646.22
Hs Code.:

Synonyms:(S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

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Chemical Property of (S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

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Technology Process of (S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

There total 9 articles about (S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105189-48-8
4-methoxy-3-<(6-methoxypyridin-3-yl)methyl>phenol

: 117653-26-6
(S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 1) boric acid, 2) 30percent H₂SO₄ / 1) ethylene glycol, 130 deg C, 0.5 h, 2) 80 deg C to room temperature

2: 75 percent / NaBH₄ / methanol; dioxane / 0.5 h / Ambient temperature

3: pyridine / 1 h / 100 °C

4: 50 percent / NaBH₄ / 1,2-dimethoxy-ethane / 17 h / 45 - 50 °C

5: MeSO₂Cl, pyridine

6: H₂ / Pd/C

7: 1) NaNO₂, H₂SO₄, 2) KI, I₂ / 1) H₂O

8: BBr₃

9: HCl / acetic acid; H₂O

With pyridine; hydrogenchloride; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; boric acid; boron tribromide; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; acetic acid;
DOI:10.1021/jm00122a009

Reference yield:

: 117653-28-8
2-formyl-4-methoxy-5-<(2-methoxypyrid-5-yl)methyl>phenol

: 117653-26-6
(S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 75 percent / NaBH₄ / methanol; dioxane / 0.5 h / Ambient temperature

2: pyridine / 1 h / 100 °C

3: 50 percent / NaBH₄ / 1,2-dimethoxy-ethane / 17 h / 45 - 50 °C

4: MeSO₂Cl, pyridine

5: H₂ / Pd/C

6: 1) NaNO₂, H₂SO₄, 2) KI, I₂ / 1) H₂O

7: BBr₃

8: HCl / acetic acid; H₂O

With pyridine; hydrogenchloride; sodium tetrahydroborate; sulfuric acid; hydrogen; iodine; boron tribromide; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; acetic acid;
DOI:10.1021/jm00122a009

Reference yield:

: 117653-30-2
4-methoxy-5-<(2-methoxypyrid-5-yl)methyl>-2-methylphenol

: 117653-26-6
(S)-2-Amino-3-{4-[4-hydroxy-2-methyl-5-(6-oxo-1,6-dihydro-pyridin-3-ylmethyl)-phenoxy]-3,5-diiodo-phenyl}-propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: MeSO₂Cl, pyridine

2: H₂ / Pd/C

3: 1) NaNO₂, H₂SO₄, 2) KI, I₂ / 1) H₂O

4: BBr₃

5: HCl / acetic acid; H₂O

With pyridine; hydrogenchloride; sulfuric acid; hydrogen; iodine; boron tribromide; methanesulfonyl chloride; potassium iodide; sodium nitrite; palladium on activated charcoal; In water; acetic acid;
DOI:10.1021/jm00122a009