2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester
• CAS No.: 271597-68-3
• Molecular Formula: C₄₀H₄₇N₇O₉S
• Molecular Weight: 801.921

Synonyms:2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Chemical Property of 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

There total 22 articles about 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (1S)-2-amino-1-methyl-2-oxoethylcarbamate (78981-25-6,81587-17-9,85642-13-3) → 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester (271597-68-3)

Guidance literature:

Multi-step reaction with 17 steps

1: 80 percent / dirhodium(II) acetate / CHCl₃ / Heating

2: 70 percent / triethylamine; triphenylphosphine; iodine / CH₂Cl₂ / 20 °C

3: 95 percent / aq. LiOH / methanol / 5 h / 20 °C

4: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

5: tetrahydrofuran / 20 °C

6: 85 percent / ammonium acetate / benzene; acetic acid / 24 h / Heating

7: ethanol / 50 °C

8: 0.5 h / 140 °C

9: 92 percent / aq. LiOH / tetrahydrofuran / 20 - 45 °C

10: triethylamine / tetrahydrofuran / 0.83 h / -10 °C

11: 32percent aq. NH₄OH / tetrahydrofuran / 0.75 h / -10 °C

12: 59 percent / Lawesson's reagent / benzene / 5 h / Heating

13: potassium hydrogen carbonate / tetrahydrofuran / 16 h / -3 °C

14: trifluoroacetic anhydride; 2,6-lutidine / tetrahydrofuran / 3 h / 0 °C

15: 94 percent / aq. LiOH / tetrahydrofuran / 20 °C

16: N-methylmorpholine / tetrahydrofuran / 0.5 h / 0 °C

17: tetrahydrofuran / 1 h / 0 °C

With Lawessons reagent; 4-methyl-morpholine; 2,6-dimethylpyridine; ammonium acetate; lithium hydroxide; iodine; potassium hydrogencarbonate; triethylamine; triphenylphosphine; trifluoroacetic anhydride; dirhodium tetraacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; acetic acid; benzene; 1: Condensation / 2: Cyclization / 3: Hydrolysis / 4: Carboxylation / 5: Substitution / 6: Amination / 7: Condensation / 8: Cyclization / 9: Hydrolysis / 10: Carboxylation / 11: Amination / 12: Substitution / 13: Condensation / 14: Cyclization / 15: Hydrolysis / 16: Carboxylation / 17: Substitution;

DOI:10.1021/ja994247b

Reference yield:

methyl 2-({[(benzyloxy)carbonyl]amino}methyl)-5-methyl-1,3-oxazole-4-carboxylate (182866-71-3) → 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester (271597-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂ / 10percent Pd/C / methanol / 4 h / 20 °C / 760.05 Torr

2: tetrahydrofuran / 1 h / 0 °C

3: 100 percent / acetyl chloride / methanol / 20 °C

4: tetrahydrofuran / 1 h / 0 °C

With hydrogen; acetyl chloride; 10percent Pd/C; In tetrahydrofuran; methanol; 1: Catalytic hydrogenation / 2: Substitution / 3: Deprotection / 4: Substitution;

DOI:10.1021/ja994247b

Reference yield:

t-Boc-L-valine (13734-41-3) → 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester (271597-68-3)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran / 0.33 h / -10 °C

2: tetrahydrofuran / 1 h / 0 °C

3: 100 percent / acetyl chloride / methanol / 20 °C

4: tetrahydrofuran / 1 h / 0 °C

With 4-methyl-morpholine; acetyl chloride; In tetrahydrofuran; methanol; 1: Carboxylation / 2: Substitution / 3: Deprotection / 4: Substitution;

DOI:10.1021/ja994247b

upstream raw materials:

t-Boc-L-valine

tert-butyl (1S)-2-amino-1-methyl-2-oxoethylcarbamate

C₁₅H₂₇NO₆

methyl 2-({[(benzyloxy)carbonyl]amino}methyl)-5-methyl-1,3-oxazole-4-carboxylate

Downstream raw materials:

C₄₀H₄₁N₉O₇S₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 271597-68-3 2-({(S)-2-[(2-{6-Benzyloxymethyl-2-[2-((S)-1-tert-butoxycarbonylamino-ethyl)-5-methyl-oxazol-4-yl]-pyridin-3-yl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-methyl)-5-methyl-oxazole-4-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send