2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine

Base Information

• Chemical Name: 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine
• CAS No.: 173009-41-1
• Molecular Formula: C₂₆H₃₀ClN₅OSSi
• Molecular Weight: 524.162

Synonyms:2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine

Chemical Property of 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine

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Technology Process of 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine

There total 3 articles about 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine (173009-34-2) → 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine (173009-41-1)

Guidance literature:

With methanol; ammonia; at 80 ℃; for 72h;

DOI:10.1080/15257779508009755

Reference yield:

2,6 dichloropurine (5451-40-1) → 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine (173009-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) EtAlCl₂ / 1.) MeCN, 60-75 deg C, 2 h, 2.) toluene, rom temperature, overnight

2: 87 percent / NH₃/MeOH / 72 h / 80 °C

With methanol; ammonia; ethylaluminum dichloride; sodium hydride;

DOI:10.1080/15257779508009755

Reference yield:

1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-L-ribofuranose (189998-53-6) → 2-chloro-6-amino-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine (173009-41-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH, 2.) EtAlCl₂ / 1.) MeCN, 60-75 deg C, 2 h, 2.) toluene, rom temperature, overnight

2: 87 percent / NH₃/MeOH / 72 h / 80 °C

With methanol; ammonia; ethylaluminum dichloride; sodium hydride;

DOI:10.1080/15257779508009755

upstream raw materials:

2,6-dichloro-9-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-α-L-ribofuranosyl>purine

2,6 dichloropurine

1-O-acetyl-5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-4-thio-L-ribofuranose

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