Technology Process of THK-5107
There total 4 articles about THK-5107 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
chloroform; water;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice
2: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Cooling with ice
3: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 85 °C / Inert atmosphere
4: trifluoroacetic acid / chloroform; water / 2 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); thionyl chloride; di-isopropyl azodicarboxylate; potassium carbonate; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 16 h / 20 °C / Cooling with ice
2: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 85 °C / Inert atmosphere
3: trifluoroacetic acid / chloroform; water / 2 h / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); di-isopropyl azodicarboxylate; potassium carbonate; triphenylphosphine; trifluoroacetic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water;
