(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid

Base Information

• Chemical Name: (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid
• CAS No.: 10209-07-1
• Molecular Formula: C₁₆H₁₆N₂O₅S
• Molecular Weight: 348.379
• Mol file: 10209-07-1.mol

Synonyms:(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid

Chemical Property of (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid

There total 1 articles about (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid (10209-07-1)

Guidance literature:

aus 2 durch Hydrolyse;

DOI:10.1021/ja01048a061

Reference yield:

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid (10209-07-1) → (6R)-3-acetoxymethyl-5ξ,8-dioxo-7t-(2-phenoxy-acetylamino)-(6rH)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester (24670-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1: -dimethyl-amine / CH₂Cl₂

2: NBS, AIBN / CCl₄

3: (i) acetone, (ii) MCPBA, CHCl₃

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N,N-dimethylformamide dineopentyl acetal; In tetrachloromethane; dichloromethane;

DOI:10.1021/ja01048a061

Reference yield:

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid (10209-07-1) → (6R)-3-acetoxymethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (10390-44-0)

Guidance literature:

Multi-step reaction with 5 steps

1: -dimethyl-amine / CH₂Cl₂

2: NBS, AIBN / CCl₄

3: (i) acetone, (ii) MCPBA, CHCl₃

4: AcCl, Na₂S₂O₄ / dimethylformamide

5: CF₃CO₂H, PhOMe / benzene

With N-Bromosuccinimide; sodium dithionite; 2,2'-azobis(isobutyronitrile); methoxybenzene; acetyl chloride; N,N-dimethylformamide dineopentyl acetal; trifluoroacetic acid; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; benzene;

DOI:10.1021/ja01048a061

Downstream raw materials:

(6R)-3-methyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 4-methoxy-benzyl ester

(6R)-3-acetoxymethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R)-3-acetoxymethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

(6R)-3-bromomethyl-8-oxo-7t-(2-phenoxy-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-3-ene-2ξ-carboxylic acid 4-methoxy-benzyl ester