(3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate

Base Information

• Chemical Name: (3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate
• CAS No.: 117151-67-4
• Molecular Formula: C₄₀H₆₄O₃Si
• Molecular Weight: 621.032
• Mol file: 117151-67-4.mol

Synonyms:(3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate

Chemical Property of (3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate

There total 2 articles about (3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C47H68O5SSi (117439-12-0,117439-13-1) → (3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate (117151-67-4)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; at 90 ℃; for 0.333333h;

DOI:10.1021/ja00183a042

Reference yield:

(3β,5α,15α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>-cholest-8-ene-3,15-diol 3-benzoate (117439-11-9,117604-43-0) → (3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate (117151-67-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: NaOMe / methanol; toluene / 25 °C

With pyridine; sodium methylate; In methanol; toluene;

DOI:10.1039/c39880000019

Reference yield: 100.0%

(3β,5α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>cholest-8-en-3-ol benzoate (117151-67-4) → (3β,5α,24R,S)-Cholest-8-ene-3,24-diol 3-benzoate (117151-68-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃;

DOI:10.1039/c39880000019

upstream raw materials:

C₄₇H₆₈O₅SSi

(3β,5α,15α,24R,S)-24-<(tert-Butyldimethylsilyl)oxy>-cholest-8-ene-3,15-diol 3-benzoate

Downstream raw materials:

(3β,5α,24R,S)-Cholest-8-ene-3,24-diol 3-benzoate

(3β,5α)-Cholesta-8,24-dien-3-ol benzoate

zymosterol

Benzoic acid (3S,5S,10S,13R,14R,17R)-17-((E)-(R)-1,5-dimethyl-hex-3-enyl)-10,13-dimethyl-2,3,4,5,6,7,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester