(E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

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Chemical Name:(E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid
CAS No.:1353003-54-9
Molecular Formula:C₂₆H₃₂N₂O₂
Molecular Weight:404.552
Hs Code.:

Synonyms:(E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

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Chemical Property of (E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

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Technology Process of (E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

There total 7 articles about (E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1353003-61-8
(E)-ethyl 2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetate

: 1353003-54-9
(E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

Guidance literature:: (E)-ethyl 2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetate; With lithium hydroxide; In ethanol; water; at 50 ℃; for 5h;

With hydrogenchloride; In ethanol; water; at 20 ℃; pH=6;
DOI:10.1016/j.tet.2011.11.004

Reference yield:

: 4497-58-9
1,2,3,4-tetrahydro-2,2,4-trimethylquinoline

: 1353003-54-9
(E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzene / 2 h / Reflux

2.1: trichlorophosphate / 5 h / 55 °C

3.1: piperidine / acetonitrile / 12 h / Reflux; Inert atmosphere

4.1: lithium hydroxide / ethanol; water / 5 h / 50 °C

4.2: 20 °C / pH 6

With piperidine; lithium hydroxide; trichlorophosphate; In ethanol; water; acetonitrile; benzene;
DOI:10.1016/j.tet.2011.11.004

Reference yield:

: 78-59-1
3,5,5-Trimethylcyclohex-2-en-1-one

: 1353003-54-9
(E)-2-cyano-2-(5,5-dimethyl-3-((E)-2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)vinyl)cyclohex-2-enylidene)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; acetic acid

2.1: piperidine / acetonitrile / 12 h / Reflux; Inert atmosphere

3.1: lithium hydroxide / ethanol; water / 5 h / 50 °C

3.2: 20 °C / pH 6

With piperidine; ammonium acetate; acetic acid; lithium hydroxide; In ethanol; water; acetonitrile; 1.1: Knoevenagel condensation;
DOI:10.1016/j.tet.2011.11.004