1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

Base Information

Chemical Name:1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine
CAS No.:188031-35-8
Molecular Formula:C₁₉H₂₂N₄O₈
Molecular Weight:434.406
Hs Code.:

Synonyms:1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

Suppliers and Price of 1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

There total 6 articles about 1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 188031-34-7
1-<3'-C-(tert-butyldimethylsilyloxymethyl)-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

: 188031-35-8
1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

Guidance literature:: With toluene-4-sulfonic acid; In methanol; for 2h; Ambient temperature;
DOI:10.1039/a900800d

Reference yield:

: 188031-43-8
1-<3'-C-(tert-butyldimethylsilyloxymethyl)-5'-O-(tert-butyldimethylsilyl)-2',3'-dideoxy-α,β-D-erythro-pentofuranosyl>cytosine

: 188031-35-8
1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / pyridine, DMAP / 18 h / Ambient temperature

2: 59 percent / p-TsOH*H₂O / methanol / 2 h / Ambient temperature

With pyridine; dmap; toluene-4-sulfonic acid; In methanol;
DOI:10.1039/a900800d

Reference yield:

: (4R,5S)-4,5-Bis-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-ol

: 188031-35-8
1-<2',3'-dideoxy-3'-C-(hydroxymethyl)-β-D-erythro-pentofuranosyl>-4-N-(p-nitrophenylethoxycarbonyl)cytosine

Guidance literature:: Multi-step reaction with 4 steps

4: p-TsOH / methanol

With toluene-4-sulfonic acid; In methanol;
DOI:10.1039/a607699h