4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide

Base Information

• Chemical Name: 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide
• CAS No.: 1625670-08-7
• Molecular Formula: C₂₈H₂₆F₃N₅O₄S
• Molecular Weight: 585.607

Synonyms:4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide

Chemical Property of 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide

Chemical Property:

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Technology Process of 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide

There total 14 articles about 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ⁶-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-cyanophenyl)-2,5-dioxo-N-(1-oxo-hexahydro-1λ4-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide (1625670-07-6) → 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ6-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide (1625670-08-7)

Guidance literature:

With mesitylenesulfonylhydroxylamine; In dichloromethane; at 20 ℃;

Reference yield:

3-[3-(trifluoromethyl)phenyl]aminocyclohex-2-en-1-one (51924-57-3) → 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ6-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide (1625670-08-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dichloromethane / 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / Cooling with ice

3.1: acetonitrile / 0.5 h / 20 °C

4.1: dihydrogen peroxide / water; ethanol / 0.5 h / -78 °C / Cooling with acetone-dry ice

4.2: 2 h / -78 °C

5.1: mesitylenesulfonylhydroxylamine / dichloromethane / 20 °C

With dmap; dihydrogen peroxide; mesitylenesulfonylhydroxylamine; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; acetonitrile;

Reference yield:

4-cyanobenzaldehyde (105-07-7) → 4-(4-cyanophenyl)-2,5-dioxo-N-(1-imino-1-oxo-hexahydro-1λ6-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide (1625670-08-7)

Guidance literature:

Multi-step reaction with 7 steps

1.1: chloro-trimethyl-silane / N,N-dimethyl-formamide; acetonitrile / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / 20 °C

3.1: sodium t-butanolate / acetonitrile / 0.33 h

4.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / Cooling with ice

5.1: acetonitrile / 0.5 h / 20 °C

6.1: dihydrogen peroxide / water; ethanol / 0.5 h / -78 °C / Cooling with acetone-dry ice

6.2: 2 h / -78 °C

7.1: mesitylenesulfonylhydroxylamine / dichloromethane / 20 °C

With dmap; chloro-trimethyl-silane; dihydrogen peroxide; mesitylenesulfonylhydroxylamine; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

4-nitrophenyl 4-(4-cyanophenyl)-2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxylate

4-(2,5-dioxo-1-(3-(trifluoromethyl)phenyl)-1,2,3,4,5,6,7,8-octahydroquinazolin-4-yl)-benzonitrile

4-(4-cyanophenyl)-2,5-dioxo-N-(tetrahydro-2H-thiopyran-4-yl)-1-(3-(trifluoromethyl)phenyl)-1,2,5,6,7,8-hexahydroquinazoline-3(4H)-carboxamide

diethyl (4-cyanophenyl)methylenedicarbamate

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