(Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile

Base Information

• Chemical Name: (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile
• CAS No.: 1415645-89-4
• Molecular Formula: C₂₀H₁₆F₃N₅O₃
• Molecular Weight: 431.374

Synonyms:(Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile

Chemical Property of (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile

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Technology Process of (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile

There total 4 articles about (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C12H12BrNO2 + 1-(4-trifluoromethylphenyl)-1,4-dihydrotetrazol-5-one (155431-49-5) → (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile (1415645-89-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1007/s00044-012-0331-4

Reference yield:

2-((3,4-dimethoxyphenyl)(hydroxy)methyl)acrylonitrile → (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile (1415645-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen bromide; sulfuric acid / dichloromethane / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With sulfuric acid; hydrogen bromide; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1007/s00044-012-0331-4

Reference yield:

p-trifluoromethyl-phenylisocyanate (1548-13-6) → (Z)-3-(3,4-dimethoxyphenyl)-2-((5-oxo-4-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-tetrazol-1-yl)methyl)acrylonitrile (1415645-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trimethylsilylazide / benzene / 24 h / 50 - 60 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With trimethylsilylazide; potassium carbonate; In N,N-dimethyl-formamide; benzene;

DOI:10.1007/s00044-012-0331-4

upstream raw materials:

1-(4-trifluoromethylphenyl)-1,4-dihydrotetrazol-5-one

p-trifluoromethyl-phenylisocyanate

3,4-dimethoxy-benzaldehyde

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