(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

Base Information

Chemical Name:(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester
CAS No.:917025-05-9
Molecular Formula:C₃₅H₄₃FO₃
Molecular Weight:530.723
Hs Code.:

Synonyms:(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

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Chemical Property of (4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

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Technology Process of (4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

There total 8 articles about (4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865235-93-4
4-(1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl)-2-methylphenol

: 917025-05-9
(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

3: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 1.5 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; palladium diacetate; triethylamine; In 1,4-dioxane; dichloromethane; water; toluene; 3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.01.042

Reference yield:

: 865240-90-0
trifluoromethanesulfonic acid 4-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-2-methylphenyl ester

: 917025-05-9
(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate / 1,4-dioxane / 80 °C / Inert atmosphere

2: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate / toluene; water / 1.5 h / 100 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; potassium acetate; palladium diacetate; In 1,4-dioxane; water; toluene; 2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2013.01.042

Reference yield:

: 865235-92-3
4-(1-ethyl-1-[4-(3-ethyl-3-hydroxy-1-pentynyl)-3-methylphenyl]propyl)-2-methylphenol

: 917025-05-9
(4'-{1-ethyl-1-[4-((E)-3-ethyl-3-hydroxy-1-pentenyl)-3-methylphenyl]propyl}-3-fluoro-2'-methylbiphenyl-4-yl)acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 20 °C / Heating / reflux

2: pyridine / dichloromethane / 2 h / 0 °C

3: potassium acetate / 1,1'-bis-(diphenylphosphino)ferrocene; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 5 h / 80 °C

4: potassium phosphate / dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate / water; toluene / 1 h / 100 °C

With pyridine; potassium phosphate; lithium aluminium tetrahydride; potassium acetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;