Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Base Information

Chemical Name:Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz
CAS No.:186410-19-5
Molecular Formula:C₃₈H₅₁N₇O₉S₂
Molecular Weight:813.996
Hs Code.:

Synonyms:Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Suppliers and Price of Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

There total 4 articles about Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz-OH*TFA

: 186410-19-5
Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Guidance literature:: With diphenyl-phosphinic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 72h; Yield given;
DOI:10.1016/S0040-4039(98)00365-7

Reference yield:

: Boc-(R)-Phe-(S)-aThr-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser-(R)-Val-Thz-OH

: 186410-19-5
Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N; DMAP / dimethylformamide / 2 h / 20 °C

2: CH₂Cl₂ / 1 h / 0 °C

3: iPr₂NEt; diphenylphosphorazide / dimethylformamide / 73.5 h / 0 - 20 °C

With dmap; diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; 1: Acetylation / 2: Substitution / 3: Acylation;
DOI:10.1039/a909363j

Reference yield:

: 275378-58-0
Boc-(R)-Phe-(S)-aThr-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser-(R)-Val-Thz-OMe

: 186410-19-5
Cyclo-(R)-Phe-(S)-aThr(Ac)-(S)-Val-Pro-Ψ(CS-NH)-(S)-Ser(Ac)-(R)-Val-Thz

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH; H₂O / tetrahydrofuran; methanol / 1 h / 0 °C

2: Et₃N; DMAP / dimethylformamide / 2 h / 20 °C

3: CH₂Cl₂ / 1 h / 0 °C

4: iPr₂NEt; diphenylphosphorazide / dimethylformamide / 73.5 h / 0 - 20 °C

With dmap; sodium hydroxide; diphenyl phosphoryl azide; water; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Acetylation / 3: Substitution / 4: Acylation;
DOI:10.1039/a909363j