2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride

Base Information

Chemical Name:2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride
CAS No.:1308669-38-6
Molecular Formula:C₁₆H₁₄ClFN₂O₂*ClH
Molecular Weight:357.212
Hs Code.:

Synonyms:2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride

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Chemical Property of 2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride

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Technology Process of 2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride

There total 2 articles about 2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 548797-51-9
2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 1308669-94-4
1-(3-bromo-5-fluoro-pyridin-4-yl)-2-ethoxy-ethanol

: 1308669-38-6
2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride

Guidance literature:: 2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; 1-(3-bromo-5-fluoro-pyridin-4-yl)-2-ethoxy-ethanol; With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

Reference yield:

: 154607-01-9
4-bromo-2-chlorobenzonitrile

: 1308669-38-6
2-chloro-4-[4-(2-ethoxy-1-hydroxy-ethyl)-5-fluoro-pyridin-3-yl]-benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4.5 h / 80 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 0.5 h / 100 °C / Inert atmosphere

With potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;