2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid

Base Information

• Chemical Name: 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid
• CAS No.: 301672-72-0
• Molecular Formula: C₁₇H₂₃ClN₂O₄
• Molecular Weight: 354.834

Synonyms:2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid

Chemical Property of 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid

There total 2 articles about 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-5-[4-[[(1,1-dimethylethoxy)-carbonyl]amino]-1-piperidinyl]-benzoic acid, ethyl ester (301672-71-9) → 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid (301672-72-0)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; ethanol; water;

Reference yield:

5-Bromo-2-chloro-benzoic acid ethyl ester (76008-73-6) → 2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid (301672-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / toluene

2: lithium hydroxide monohydrate / tetrahydrofuran; ethanol; water

With lithium hydroxide monohydrate; caesium carbonate; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

2-chloro-5-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-piperidinyl]-benzoic acid (301672-72-0) + adamantylmethylamine (17768-41-1) → [1-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-4-piperidinyl]-carbamic acid, 1,1-dimethylethyl ester (301672-73-1)

Guidance literature:

With 1,1'-carbonyldiimidazole; In N-methyl-acetamide;

upstream raw materials:

2-chloro-5-[4-[[(1,1-dimethylethoxy)-carbonyl]amino]-1-piperidinyl]-benzoic acid, ethyl ester

5-Bromo-2-chloro-benzoic acid ethyl ester

Downstream raw materials:

[1-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]-4-piperidinyl]-carbamic acid, 1,1-dimethylethyl ester

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