(2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester

Base Information

• Chemical Name: (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester
• CAS No.: 161510-66-3
• Molecular Formula: C₂₅H₃₄N₂O₅
• Molecular Weight: 442.555

Synonyms:(2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester

Chemical Property of (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester

Chemical Property:

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Technology Process of (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester

There total 10 articles about (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.5%

(2S,3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,3-epoxy-5-phenylpentanoic acid ethyl ester (161510-63-0) + benzylamine (100-46-9) → (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester (161510-66-3)

Guidance literature:

In ethanol; at 60 ℃; for 72h;

DOI:10.1016/j.bmcl.2006.11.020

Reference yield: 83.0%

(2S/R,3R/S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,3-epoxy-5-phenylpentanoic acid ethyl ester + benzylamine (100-46-9) → (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester (161510-66-3)

Guidance literature:

In ethanol; at 60 ℃; for 48h;

DOI:10.1021/jm00045a013

Reference yield: 59.0%

(2S/R,3R/S,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,3-epoxy-5-phenylpentanoic acid ethyl ester + benzylamine (100-46-9) → (2R,3S,4S)-2-(benzylamino)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-3-hydoxy-5-phenylpentanoic acid ethyl ester (161510-66-3) + SDZ 282658 (161510-70-9)

Guidance literature:

In tetrahydrofuran; at 60 ℃; for 72h;

DOI:10.1021/jm00045a013

upstream raw materials:

benzylamine

(2S,3R,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2,3-epoxy-5-phenylpentanoic acid ethyl ester

N-tert-butoxycarbonyl-L-phenylalanine

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Downstream raw materials:

[(S)-1-[(1S,2R,3R)-1-Benzyl-3-benzylamino-3-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-2-hydroxy-propylcarbamoyl]-2-(1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester

(2R,3R,4S)-4-{(S)-2-[3-(1H-Benzoimidazol-2-ylmethyl)-3-methyl-ureido]-3-methyl-butyrylamino}-2-benzylamino-3-hydroxy-5-phenyl-pentanoic acid ((S)-1-benzylcarbamoyl-2-methyl-propyl)-amide

SDZ 283365

SDZ 282395

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