4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Base Information

Chemical Name:4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide
CAS No.:1354546-68-1
Molecular Formula:C₂₈H₃₁NO₅S
Molecular Weight:493.624
Hs Code.:

Synonyms:4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Chemical Property of 4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

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Technology Process of 4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

There total 3 articles about 4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354546-26-1
ethyl 4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)butanoate

: 1354546-68-1
4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

2.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h

2.2: 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water;
DOI:10.1021/jm2014748

Reference yield:

: 66693-06-9
ethyl 2-(benzenesulfonyl)propanate

: 1354546-68-1
4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

3.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h

3.2: 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2014748

Reference yield:

: 873-55-2
sodium benzenesulfonate

: 1354546-68-1
4-biphenyl-4-yl-2-methyl-2-(phenylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 16 h / 85 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3.1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4.1: 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine / 2-methyltetrahydrofuran / 1 h

4.2: 20 °C

With 4-methyl-morpholine; 2-chloro-4,6-dimethoxy-1 ,3,5-triazine; caesium carbonate; lithium hydroxide; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2014748