Technology Process of 2-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine
There total 8 articles about 2-phenyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate;
In
toluene;
for 18h;
Inert atmosphere;
Reflux;
DOI:10.1021/ol501073f
- Guidance literature:
-
3-[2-(hydroxymethyl)phenyl]propan-1-ol;
With
methanesulfonyl chloride; triethylamine;
In
dichloromethane;
at 0 ℃;
for 3h;
Inert atmosphere;
aniline;
In
methanol;
at 20 ℃;
for 7h;
DOI:10.1080/00397911.2014.928327
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 6 h / 100 °C / Inert atmosphere
2.1: 5%-palladium/activated carbon; hydrogen / methanol / 1 h / 1034.32 - 1551.49 Torr
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
4.1: methanesulfonyl chloride; triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere
4.2: 7 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; 5%-palladium/activated carbon; hydrogen; methanesulfonyl chloride; triethylamine;
In
tetrahydrofuran; methanol; dichloromethane; toluene;
1.1: |Heck Reaction;
DOI:10.1080/00397911.2014.928327