N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine

Base Information

• Chemical Name: N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine
• CAS No.: 1448338-14-4
• Molecular Formula: C₂₈H₃₄N₈
• Molecular Weight: 482.632

Synonyms:N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine

Chemical Property of N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine

Chemical Property:

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Technology Process of N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine

There total 7 articles about N²-(4-aminocyclohexyl)-9-cyclopentyl-N₆-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N2-(4-aminocyclohexyl)-N6-(6-bromo-pyridin-3-ylmethyl)-9-cyclopentyl-9H-purine-2,6-diamine (1448338-04-2) + phenylboronic acid (98-80-6) → N2-(4-aminocyclohexyl)-9-cyclopentyl-N6-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine (1448338-14-4)

Guidance literature:

With potassium phosphate tribasic trihydrate; tetrabutylammomium bromide; palladium diacetate; In N,N-dimethyl-formamide; at 120 ℃; for 5h; Sealed tube; Inert atmosphere;

DOI:10.1021/jm4006884

Reference yield:

9-(cyclopentyl)-2,6-(dichloro)-9H-purine (211733-67-4) → N2-(4-aminocyclohexyl)-9-cyclopentyl-N6-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine (1448338-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / propan-1-ol / 4 h / 120 °C / Sealed tube; Inert atmosphere

2: 4 h / 160 °C / Sealed tube; Inert atmosphere

3: potassium phosphate tribasic trihydrate; palladium diacetate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 5 h / 120 °C / Sealed tube; Inert atmosphere

With potassium phosphate tribasic trihydrate; tetrabutylammomium bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; In propan-1-ol; N,N-dimethyl-formamide;

DOI:10.1021/jm4006884

Reference yield:

2-Bromo-5-methylpyridine (3510-66-5) → N2-(4-aminocyclohexyl)-9-cyclopentyl-N6-(6-phenylpyridin-3-ylmethyl)-9H-purine-2,6-diamine (1448338-14-4)

Guidance literature:

Multi-step reaction with 5 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / 1,2-dichloro-ethane / 0.25 h / 85 °C

2: hexamethylenetetramine / chloroform / 16 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / propan-1-ol / 4 h / 120 °C / Sealed tube; Inert atmosphere

4: 4 h / 160 °C / Sealed tube; Inert atmosphere

5: potassium phosphate tribasic trihydrate; palladium diacetate; tetrabutylammomium bromide / N,N-dimethyl-formamide / 5 h / 120 °C / Sealed tube; Inert atmosphere

With N-Bromosuccinimide; potassium phosphate tribasic trihydrate; 2,2'-azobis(isobutyronitrile); hexamethylenetetramine; tetrabutylammomium bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; In propan-1-ol; chloroform; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm4006884

upstream raw materials:

N²-(4-aminocyclohexyl)-N⁶-(6-bromo-pyridin-3-ylmethyl)-9-cyclopentyl-9H-purine-2,6-diamine

phenylboronic acid

9-(cyclopentyl)-2,6-(dichloro)-9H-purine

2-Bromo-5-methylpyridine

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