1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol

Base Information

• Chemical Name: 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol
• CAS No.: 1414941-75-5
• Molecular Formula: C₂₄H₂₈N₄O₃
• Molecular Weight: 420.511
• Mol file: 1414941-75-5.mol

Synonyms:1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol

Chemical Property of 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol

There total 4 articles about 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,3-epoxypropyl p-methoxyphenyl ether (2211-94-1,26744-15-0) + 1-[3-(4-pyridyl)-2-pyridyl]piperazine (1414942-29-2) → 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol (1414941-75-5)

Guidance literature:

In ethanol; for 5h; Reflux;

DOI:10.1016/j.ejmech.2014.03.066

Reference yield:

4-methoxy-phenol (150-76-5) → 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol (1414941-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 3 h / 100 °C

2: ethanol / 5 h / Reflux

With sodium hydroxide; In ethanol; water;

DOI:10.1016/j.ejmech.2014.03.066

Reference yield:

4-pyridylboronic acid (1692-15-5) + 1-(3-bromo-2-pyridyl)piperazine (87394-56-7) → 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol (1414941-75-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / Inert atmosphere; Reflux

2: ethanol / 5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; 1: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2014.03.066

upstream raw materials:

4-pyridylboronic acid

1-(3-bromo-2-pyridyl)piperazine

2,3-epoxypropyl p-methoxyphenyl ether

1-[3-(4-pyridyl)-2-pyridyl]piperazine