[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Base Information

Chemical Name:[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone
CAS No.:1315469-37-4
Molecular Formula:C₂₀H₁₅Cl₂N₃O₂
Molecular Weight:400.264
Hs Code.:

Synonyms:[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

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Chemical Property of [4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

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Technology Process of [4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

There total 11 articles about [4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: C₁₁H₅Cl₃N₂O₂

: 1315469-37-4
[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Guidance literature:: With triethylamine; at 20 ℃; for 3h;
DOI:10.1021/jm301071h

Reference yield: 2.0%

: 635-46-1
1,2,3,4-tetrahydroisoquinoline

: 1315469-70-5
4-(2,5-dichlorophenoxy)pyrimidine-5-carboxylate

: 1315469-37-4
[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 583-78-8
2,5-dichlorophenol

: 1315469-37-4
[4-(2,5-dichloro-phenoxy)-pyrimidin-5-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / tetrakis(actonitrile)copper(I) hexafluorophosphate / toluene / 2.5 h / Reflux

2: sodium hydroxide; water / tetrahydrofuran / 0.5 h / 80 °C / Microwave irradiation

3: triethylamine; 2-chloro-1-methyl-pyridinium iodide / dichloromethane / 2 h / 20 °C

With 2-chloro-1-methyl-pyridinium iodide; water; caesium carbonate; triethylamine; sodium hydroxide; tetrakis(actonitrile)copper(I) hexafluorophosphate; In tetrahydrofuran; dichloromethane; toluene;