[[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

Base Information

Chemical Name:[[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester
CAS No.:132353-94-7
Molecular Formula:C₂₁H₂₄ClNO₄S₃
Molecular Weight:486.077
Hs Code.:

Synonyms:[[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

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Chemical Property of [[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

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Technology Process of [[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

There total 7 articles about [[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: methyl (E)-N-<2-(2-methylthio-2-methylsulphinylvinyl)-4-methylphenyl>-N-(toluene-4-sulphonyl)-2-aminoacetate

: 132353-94-7
[[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

Guidance literature:: With hydrogenchloride; In dichloromethane; for 2h;

Reference yield:

: 2941-78-8
2-Amino-5-methylbenzoic acid

: 132353-94-7
[[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / Na₂CO₃ / H₂O / 0.33 h / 70 °C

2: LiAlH₄ / tetrahydrofuran / 1 h / Heating

3: 93.4 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h

4: 77 percent / Triton B / tetrahydrofuran / 60 h / Heating

5: 1) NaH / 1) DMF, 5 min; 2) 40 deg C, 10 min

6: 100 percent / 10M aq. HCl / CH₂Cl₂ / 2 h

With hydrogenchloride; lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; sodium hydride; sodium carbonate; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 34161-81-4
5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid

: 132353-94-7
[[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 93.4 percent / pyridinium chlorochromate / CH₂Cl₂ / 3 h

3: 77 percent / Triton B / tetrahydrofuran / 60 h / Heating

4: 1) NaH / 1) DMF, 5 min; 2) 40 deg C, 10 min

5: 100 percent / 10M aq. HCl / CH₂Cl₂ / 2 h

With hydrogenchloride; lithium aluminium tetrahydride; N-benzyl-trimethylammonium hydroxide; sodium hydride; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane;