(1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester
CAS No.:578729-19-8
Molecular Formula:C₂₅H₂₈F₂N₆O₃
Molecular Weight:498.533
Hs Code.:

(1-{1-[3,3'-difluoro-2'-(2-methyl-2<i>H</i>-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

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Chemical Property of (1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

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Technology Process of (1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

There total 11 articles about (1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 578729-17-6
5-(2-fluoro-6-iodo-phenyl)-1H-tetrazole

: 578729-19-8
(1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 26.2 percent / potassium carbonate / dimethylformamide / 3 h / 20 °C

2: potassium carbonate; tri-o-tolylphosphine / palladium acetate / tetrahydrofuran; H₂O / 4 h / 100 °C

3: HCl (gas) / ethyl acetate / 0.5 h / 20 °C

4: 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole; triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1021/jm061094b

Reference yield:

: 578729-18-7
5-(2-fluoro-6-iodophenyl)-2-methyl-2H-tetrazole

: 578729-19-8
(1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tri-o-tolylphosphine / palladium acetate / tetrahydrofuran; H₂O / 4 h / 100 °C

2: HCl (gas) / ethyl acetate / 0.5 h / 20 °C

3: 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole; triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; ethyl acetate; 1: Suzuki coupling;
DOI:10.1021/jm061094b

Reference yield:

: 935431-10-0
N-[(1E)-(4-bromo-2-fluorophenyl)methylidene]-2-methylpropane-2-sulfinamide

: 578729-19-8
(1-{1-[3,3'-difluoro-2'-(2-methyl-2H-tetrazol-5-yl)-biphenyl-4-yl]-ethylcarbamoyl}-cyclopropyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 65 percent / CH₂Cl₂; diethyl ether / 1 h / -48 °C

2: 98 percent / HCl / dioxane; methanol

3: triethylamine / CH₂Cl₂ / 0 °C

4: 32.0 g / potassium acetate / [1,1'-bis(diphenylphosphino)ferrocene]PdCl₂ / dimethylsulfoxide / 3 h / 90 °C

5: potassium carbonate; tri-o-tolylphosphine / palladium acetate / tetrahydrofuran; H₂O / 4 h / 100 °C

6: HCl (gas) / ethyl acetate / 0.5 h / 20 °C

7: 1-ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride; 1-hydroxy-7-azabenzotriazole; triethylamine / CH₂Cl₂ / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; potassium acetate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tris-(o-tolyl)phosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; 5: Suzuki coupling;
DOI:10.1021/jm061094b