(S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

Base Information

Chemical Name:(S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester
CAS No.:223777-96-6
Molecular Formula:C₂₈H₃₆N₄O₉
Molecular Weight:572.615
Hs Code.:

Synonyms:(S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

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Chemical Property of (S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

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Technology Process of (S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

There total 1 articles about (S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 66493-64-9
Boc-A₂pr(-Z)-ONSu

: 71749-02-5
N^β-Z-Dap-OMe*HCl

: 223777-96-6
(S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; a) 0 deg C, 1 h, b) RT, overnight;
DOI:10.1021/ja9842114

Reference yield:

: 223777-96-6
(S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

: (S)-2-((S)-2-Amino-3-benzyloxycarbonylamino-propionylamino)-3-benzyloxycarbonylamino-propionic acid methyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; for 1h; Ambient temperature;
DOI:10.1021/ja9842114

Reference yield:

: 223777-96-6
(S)-3-Benzyloxycarbonylamino-2-((S)-3-benzyloxycarbonylamino-2-tert-butoxycarbonylamino-propionylamino)-propionic acid methyl ester

: 2-{2-[2-(4-bromo-benzoylamino)-acryloylamino]-acryloylamino}-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: HCl / ethyl acetate / 1 h / Ambient temperature

2: Et₃N / dimethylformamide / a) 0 deg C, 1 h, b) RT, overnight

3: HCl / ethyl acetate / 1 h / Ambient temperature

4: 93 percent / Et₃N / dimethylformamide / a) 0 deg C, 2 h, b) RT, overnight

5: 25 percent HBr, AcOH / 2 h / Ambient temperature

6: CH₃I, KHCO₃ / methanol; dimethylformamide / 6 h / Ambient temperature

With hydrogenchloride; hydrogen bromide; potassium hydrogencarbonate; acetic acid; triethylamine; methyl iodide; In methanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja9842114