tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Base Information

Chemical Name:tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate
CAS No.:1620056-47-4
Molecular Formula:C₁₈H₁₈Br₂F₂N₂O₂
Molecular Weight:492.158
Hs Code.:

Synonyms:tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Suppliers and Price of tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 9 raw suppliers

Chemical Property of tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

There total 5 articles about tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-1-(3,6-dibromopyridin-2-yl)-2-(3,5-difluorophenyl)ethan-1-amine

: 1620056-47-4
tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In 2-methyltetrahydrofuran; water; at 0 - 20 ℃; for 2h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: (S)-1-(3,6-dibromopyridin-2-yl)-2-(3,5-difluorophenyl)ethanamine hydrochloride

: 1620056-47-4
tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1215183-85-9
3,6-dibromopyridine-2-carbaldehyde

: 1620056-47-4
tert-butyl (S)-( 1 -(3,6-dibromopyridin-2-yl)-2-(3,5 -difluorophenyl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate; 1-methyl-pyrrolidin-2-one / 2 h

2.1: N,N-dimethyl-formamide / 0.08 h

2.2: 4 h

3.1: hydrogenchloride; cyclopentyl methyl ether / acetonitrile; water / 4.17 h / 20 °C

4.1: sodium hydrogencarbonate / water; 2-methyltetrahydrofuran / 4 h / 0 - 20 °C

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; cyclopentyl methyl ether; sodium hydrogencarbonate; caesium carbonate; In 2-methyltetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;