N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

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Chemical Name:N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide
CAS No.:1218806-26-8
Molecular Formula:C₂₀H₂₄FN₃O₂
Molecular Weight:357.428
Hs Code.:

Synonyms:N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

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Chemical Property of N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

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Technology Process of N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

There total 4 articles about N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 5813-64-9
2.2-dimethylpropylamine

: 1218810-51-5
(7-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)acetic acid

: 1993-03-9
o-fluorophenylboronic acid

: 1218806-26-8
N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

Guidance literature:: 2.2-dimethylpropylamine; With sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; at 20 ℃; for 18h;

(7-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)acetic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

o-fluorophenylboronic acid; Further stages;
DOI:10.1016/j.bmc.2013.09.054

Reference yield:

: 1218810-47-9
ethyl (2E)-4-{[(4-iodo-1H-pyrrol-2-yl)carbonyl]amino}but-2-enoate

: 1218806-26-8
N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 20 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

3.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 18 h / 20 °C

3.2: 24 h / 20 °C

With lithium hydroxide monohydrate; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; water; acetonitrile; 1.1: |Michael Addition;
DOI:10.1016/j.bmc.2013.09.054

Reference yield:

: 1218810-48-0
ethyl (7-iodo-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl)acetate

: 1218806-26-8
N-(2,2-dimethylpropyl)-2-[7-(2-fluorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C

2.1: sodium tris(acetoxy)borohydride; acetic acid / tetrahydrofuran / 18 h / 20 °C

2.2: 24 h / 20 °C

With lithium hydroxide monohydrate; sodium tris(acetoxy)borohydride; acetic acid; In tetrahydrofuran; water;
DOI:10.1016/j.bmc.2013.09.054