1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol

Base Information

• Chemical Name: 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol
• CAS No.: 1426082-16-7
• Molecular Formula: C₂₉H₂₅F₅N₄O₂S
• Molecular Weight: 588.601
• Mol file: 1426082-16-7.mol

Synonyms:1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol

Chemical Property of 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol

There total 9 articles about 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

{2-[4-(4-bromo-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine (1251931-23-3) + 2,2,3,3,3-pentafluoro-1-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[b]thiophen-3-yl]-propan-1-ol (1426082-59-8) → 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol (1426082-16-7)

Guidance literature:

With palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; for 2h; Reflux;

DOI:10.1016/j.bmc.2012.12.035

Reference yield:

{2-[4-(4-bromo-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine (1251931-22-2) → 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol (1426082-16-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; water / 60 °C

2: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

With hydrogenchloride; water; palladium diacetate; potassium carbonate; triphenylphosphine; In 1,2-dimethoxyethane; water; 2: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.12.035

Reference yield:

4-bromo-2-fluorobenzaldehyde (57848-46-1) → 1-(6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-benzo[b]thiophen-3-yl)-2,2,3,3,3-pentafluoro-propan-1-ol (1426082-16-7)

Guidance literature:

Multi-step reaction with 8 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 5.5 h / 60 °C

2.1: potassium hydroxide / water; ethanol / 1.5 h / Reflux

3.1: copper; quinoline / 2 h / 185 °C

4.1: N-Bromosuccinimide; acetic acid / chloroform / 20 °C / Cooling with ice

5.1: n-butyllithium / diethyl ether; hexane / 0.75 h / -70 °C

5.2: 4 h / -70 °C

6.1: sodium hydroxide; sodium tetrahydroborate / methanol / 1.5 h / 20 °C

7.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 90 °C

8.1: potassium carbonate; triphenylphosphine; palladium diacetate / water; 1,2-dimethoxyethane / 2 h / Reflux

With quinoline; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; potassium acetate; palladium diacetate; copper; potassium carbonate; acetic acid; triphenylphosphine; potassium hydroxide; sodium hydroxide; In methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; hexane; chloroform; water; N,N-dimethyl-formamide; 8.1: |Suzuki Coupling;

DOI:10.1016/j.bmc.2012.12.035

upstream raw materials:

{2-[4-(4-bromo-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

2,2,3,3,3-pentafluoro-1-[6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzo[b]thiophen-3-yl]-propan-1-ol

{2-[4-(4-bromo-1-methoxymethyl-5-pyridin-4-yl-1H-imidazol-2-yl)-phenoxy]-ethyl}-dimethyl-amine

4-bromo-2-fluorobenzaldehyde