3-Isoxazoleacetic acid, 5-hydroxy- (9CI)

Base Information

• Chemical Name: 3-Isoxazoleacetic acid, 5-hydroxy- (9CI)
• CAS No.: 178168-21-3
• Molecular Formula: C₅H₅NO₄
• Molecular Weight: 143.099
• Mol file: 178168-21-3.mol

Synonyms:3-Isoxazoleacetic acid, 5-hydroxy- (9CI)

Chemical Property of 3-Isoxazoleacetic acid, 5-hydroxy- (9CI)

Chemical Property:

• PSA: 83.56000
• LogP: 0.00730

Purity/Quality:

97% ^*data from raw suppliers

(5-Hydroxy-isoxazol-3-yl)-aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: (5-Hydroxy-isoxazol-3-yl)-acetic acid is a useful reagent in the preparation of novel peptide epoxyketone derivatives used as inhibitors of proteasomes for treating various conditions or diseases associated with proteasomes

Technology Process of 3-Isoxazoleacetic acid, 5-hydroxy- (9CI)

There total 2 articles about 3-Isoxazoleacetic acid, 5-hydroxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C7H11NO5 (73870-13-0) → 2-(5-hydroxyisoxazol-3-yl)acetic acid (178168-21-3)

Guidance literature:

With methanol; sodium hydroxide; for 3h;

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) → 2-(5-hydroxyisoxazol-3-yl)acetic acid (178168-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride / methanol; water / 20 °C

2: methanol; sodium hydroxide / 3 h

With methanol; hydroxylamine hydrochloride; sodium hydroxide; In methanol; water;

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

C₇H₁₁NO₅