2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Base Information

Chemical Name:2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester
CAS No.:1296216-84-6
Molecular Formula:C₁₉H₁₇BrClNO₂
Molecular Weight:406.706
Hs Code.:

Synonyms:2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Suppliers and Price of 2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

There total 4 articles about 2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1296216-50-6
benzyl 2-(2-bromo-6-chlorophenyl)-1,2,3,6-tetrahydropyridine-1(2H)-carboxylate

: 1296216-84-6
2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 120 ℃; for 0.833333h; Inert atmosphere; Microwave irradiation;
DOI:10.1021/ol200709h

Reference yield:

: 1296216-47-1
allyl-[1-(2-bromo-6-chloro-phenyl)-but-3-enyl]-carbamic acid benzyl ester

: 1296216-84-6
2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Guidance literature:: Multi-step reaction with 2 steps

1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 14.5 h / 20 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol200709h

Reference yield:

: 64622-16-8
2-bromo-6-chlorobenzaldehyde

: 1296216-84-6
2-(2-bromo-6-chloro-phenyl)-3,4-dihydro-2H-pyridine-1-carboxylic acid benzylester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 12 h / 20 °C / Molecular sieve

2.1: tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

2.2: 2 h / -78 °C / Inert atmosphere

2.3: 0 °C / Saturated solution

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 14.5 h / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 0.83 h / 120 °C / Inert atmosphere; Microwave irradiation

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; triethylamine; In tetrahydrofuran; dichloromethane; 2.2: Mannich type reaction;
DOI:10.1021/ol200709h